Manual Cell-wide metabolic alterations associated with malignancy

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Pan-cancer analysis of tumor metabolic landscape associated with genomic alterations

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received. Methods to assess the autophagic flux in malignant cells 5.


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Methods to assess autophagy in situ-transmission electron microscopy versus immunohistochemistry 6. Methods to measure the enzymatic activity of PI3Ks 7. Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter 8.

1st Edition

Metabolomic profiling of cultured cancer cells 9. Pulsed stable isotope-resolved metabolomic studies of cancer cells Single-cell imaging for the study of oncometabolism Study of cellular oncometabolism via multi-dimensional protein identification technology In vivo quantitative proteomics for the study of oncometabolism Metabolomic profiling of neoplastic lesions in mice Metabolomic profiling of tumor-bearing mice Analysis of metabolomic profiling data acquired on GC-MS.

This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations.

Adrienne Scheck - Metabolic therapy for the adjuvant treatment of malignant brain tumors

Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. The following ISBNs are associated with this title:. ISBN - On the Content tab, click to select the Enable JavaScript check box.

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